Free SKILL.md scraped from GitHub. Clone the repo or copy the file directly into your Claude Code skills directory.
npx versuz@latest install a5c-ai-babysitter-library-specializations-domains-science-bioinformatics-skills-bwgit clone https://github.com/a5c-ai/babysitter.gitcp babysitter/SKILL.MD ~/.claude/skills/a5c-ai-babysitter-library-specializations-domains-science-bioinformatics-skills-bw/SKILL.md---
name: bwa-aligner
description: BWA-MEM2 alignment skill for mapping sequencing reads to reference genomes with optimized parameter selection
allowed-tools:
- Read
- Write
- Glob
- Grep
- Edit
- WebFetch
- WebSearch
- Bash
metadata:
version: "1.0"
category: bioinformatics
tags:
- sequence-analysis
- alignment
- genomics
- ngs
---
# BWA Aligner Skill
## Purpose
Enable BWA-MEM2 alignment for mapping sequencing reads to reference genomes with optimized parameter selection and quality assessment.
## Capabilities
- Read alignment to reference genomes
- Parameter optimization for different read types
- Multi-threading configuration
- Index generation and management
- Alignment quality metrics reporting
- Support for paired-end and single-end reads
## Usage Guidelines
- Generate genome indices before alignment
- Select appropriate parameters for read length and type
- Use multi-threading for performance optimization
- Validate alignment quality metrics post-processing
- Document parameter choices and rationale
- Archive index files for reproducibility
## Dependencies
- BWA-MEM2
- minimap2
- samtools
## Process Integration
- Whole Genome Sequencing Pipeline (wgs-analysis-pipeline)
- Long-Read Sequencing Analysis (long-read-analysis)
- Tumor Molecular Profiling (tumor-molecular-profiling)